Background Conventional imaging using CT and bone scan has insufficient sensitivity
when staging men with high-risk localised prostate cancer. We aimed to investigate whether …

Africa is the source of all modern humans, but characterization of genetic variation and of
relationships among populations across the continent has been enigmatic. We studied 121 …

Background Enzalutamide, an androgen-receptor inhibitor, has been associated with improved
overall survival in men with castration-resistant prostate cancer. It is not known whether …

The majority of studies of genetic association with disease have been performed in Europeans.
This European bias has important implications for risk prediction of diseases across …

Background Progressive metastatic castration-resistant prostate cancer is a highly lethal
disorder and new effective therapeutic agents that improve patient outcomes are urgently …

10.7554/eLife.09560.001 Homo naledi is a previously-unknown species of extinct hominin
discovered within the Dinaledi Chamber of the Rising Star cave system, Cradle of Humankind…

Background Lutetium-177 [ 177 Lu]Lu-PSMA-617 is a radiolabelled small molecule that delivers
β radiation to cells expressing prostate-specific membrane antigen (PSMA), with activity …

The frequencies of low-activity alleles of glucose-6-phosphate dehydrogenase in humans
are highly correlated with the prevalence of malaria. These “deficiency” alleles are thought to …

Motivation: The sequencing of the human genome has made it possible to identify an informative
set of >1 million single nucleotide polymorphisms (SNPs) across the genome that can …

Background The absence of trial data comparing robot-assisted laparoscopic prostatectomy
and open radical retropubic prostatectomy is a crucial knowledge gap in uro-oncology. We …