Many bioactive peptides must be amidated at their carboxy terminus to exhibit full activity.
Surprisingly, the amides are not generated by a transamidation reaction. Instead, the …

… The material in yeast extract that enabled S. faecalis to oxidize pyruvate could not be replaced
by any known vitamins or cofactors and was called pyruvate oxidation factor (POF) (160). …

In mammals, lipoxygenases catalyze the formation of hydroperoxides as the first step in the
biosynthesis of several inflammatory mediators. The substrate of this reaction, arachidonic …

Copper active sites play a major role in enzymatic activation of dioxygen. We trapped the
copper-dioxygen complex in the enzyme peptidylglycine-alphahydroxylating monooxygenase (…

Many neuropeptides and peptide hormones require amidation at the carboxyl terminus for
activity. Peptidylglycine α-amidating monooxygenase (PAM) catalyzes the amidation of these …

Peptide amidation is a ubiquitous posttranslational modification of bioactive peptides.
Peptidylglycine α-hydroxylating monooxygenase (PHM; EC 1.14. 17.3), the enzymne that …

Cyclin dependent protein kinases (CDKs) have become attractive drug targets in an effort to
identify effective inhibitors of the parasite Plasmodium falciparum, the causative agent of the …

The apicoplast organelle of the malaria parasite Plasmodium falciparum contains metabolic
pathways critical for liver-stage and blood-stage development. During the blood stages, …

… Such genetic strategies are needed to identify primary target(s) of choline analogs. … We
thank past and present members of the Ben Mamoun, Prigge, and Vial laboratories for …

… complementary strategy to other interventions, such as supplementation and dietary
diversification, and can deliver sustainable improvements in health to large segments of the world’s …