RNA-binding proteins of the L7Ae family are at the heart of many essential ribonucleoproteins
(RNPs), including box C/D and H/ACA small nucleolar RNPs, U4 small nuclear RNP, …

Background There appears little consensus concerning protein requirements in phenylketonuria
(PKU). Methods A questionnaire completed by 63 European and Turkish IMD centres …

Galectins are a family of carbohydrate-binding proteins with an affinity for β-galactosides.
Galectin-1 (Gal-1) is differentially expressed by various normal and pathological tissues and …

Marine fungi are known to produce structurally unique secondary metabolites, and more than
1000 marine fungal-derived metabolites have already been reported. Despite the absence …

Animal cell culture technology has advanced significantly over the last few decades and is
now generally considered a reliable, robust and relatively mature technology. A range of …

Among 25 3-aryl-2-quinolone derivatives synthesized, the antitumor activity of some of them
was characterized both in vitro and in vivo. In this series, no compound appeared to be …

Melanomas display poor response rates to adjuvant therapies because of their intrinsic
resistance to proapoptotic stimuli. This study indicates that such resistance can be overcome, at …

The sodium–glucose cotransporter 2 inhibitor empagliflozin reduces the risk of cardiovascular
death or heart failure hospitalization in patients with chronic heart failure, but whether …

Background The potential benefit of dual antiplatelet therapy beyond 1 year after a myocardial
infarction has not been established. We investigated the efficacy and safety of ticagrelor, a …

Narciclasine (1) is a plant growth regulator that has been previously demonstrated to be
proapoptotic to cancer cells at high concentrations (≥1 μM). Data generated in the present …