Oligonucleotide and complementary DNA microarrays are being used to subclassify histologically
similar tumours, monitor disease progress, and individualize treatment regimens 1 , 2 , …

Mecp2 is an X-linked gene encoding a nuclear protein that binds specifically to methylated
DNA (ref. 1) and functions as a general transcriptional repressor by associating with …

Genome-wide demethylation has been suggested to be a step in carcinogenesis 1 . Evidence
for this notion comes from the frequently observed global DNA hypomethylation in tumour …

BACKGROUND & AIMS: Chemoembolization is one of several standards of care treatment
for hepatocellular carcinoma (HCC). Radioembolization with Yttrium-90 microspheres is a …

We tested dexmedetomidine, an α 2 agonist that decreases heart rate, blood pressure, and
plasma norepinephrine concentration, for its ability to attenuate stress responses during …

DNA methyltransferase I (Dnmt1), the maintenance enzyme for DNA cytosine methylation, is
expressed at high levels in the CNS during embryogenesis and after birth. Because …

The Mecp2 gene has been shown to be mutated in most cases of human Rett syndrome, and
mouse models deleted for the ortholog have been generated. Lineage-specific deletion of …

Despite advances in the differentiation of insulin-producing cells from human embryonic
stem cells, the generation of mature functional β cells in vitro has remained elusive. To …

Deep-learning methods for computational pathology require either manual annotation of
gigapixel whole-slide images (WSIs) or large datasets of WSIs with slide-level labels and …

Vision Transformers (ViTs) and their multi-scale and hierarchical variations have been
successful at capturing image representations but their use has been generally studied for low-…