Screens for agents that specifically kill epithelial cancer stem cells (CSCs) have not been
possible due to the rarity of these cells within tumor cell populations and their relative instability …

Generation of induced pluripotent stem cells (iPSCs) by somatic cell reprogramming
involves global epigenetic remodelling 1 . Whereas several proteins are known to regulate …

When n identical randomly located nodes, each capable of transmitting at W bits per second
and using a fixed range, form a wireless network, the throughput /spl lambda/(n) obtainable …

The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are
aggressive and respond poorly to standard therapies. Although the identification of specific …

Cancer cells within individual tumors often exist in distinct phenotypic states that differ in
functional attributes. While cancer cell populations typically display distinctive equilibria in the …

The aggressive clinical behavior of melanoma suggests that the developmental origins of
melanocytes in the neural crest might be relevant to their metastatic propensity. Here we show …

Fibroblasts often constitute the majority of the stromal cells within a breast carcinoma, yet
the functional contributions of these cells to tumorigenesis are poorly understood. Using a …

Coding strategies that exploit node cooperation are developed for relay networks. Two basic
schemes are studied: the relays decode-and-forward the source message to the destination…

Loss of the epithelial adhesion molecule E-cadherin is thought to enable metastasis by
disrupting intercellular contacts—an early step in metastatic dissemination. To further investigate …

Hydrogels are one of the upcoming classes of polymer-based controlled-release drug delivery
systems. Besides exhibiting swelling-controlled drug release, hydrogels also show stimuli-…