User profiles for M. Stumpp

Meike Stumpp

Christian-Albrechts-Universität zu Kiel - Comparative Immunobiology
Verified email at zoologie.uni-kiel.de
Cited by 2325

Comprehensive survey of proteins targeted by chloroplast thioredoxin

K Motohashi, A Kondoh, MT Stumpp… - Proceedings of the …, 2001 - National Acad Sciences
… For that purpose, we immobilized a mutant of m-type Trx in which an internal cysteine at
the active site was substituted with serine, on cyanogen bromide-activated resin. By using this …

DARPins: a new generation of protein therapeutics

MT Stumpp, HK Binz, P Amstutz - Drug discovery today, 2008 - Elsevier
DARPins (designed ankyrin repeat proteins) are a novel class of binding molecules with the
potential to overcome limitations of monoclonal antibodies, hence allowing novel …

[HTML][HTML] Neovascular age-related macular degeneration: therapeutic management and new-upcoming approaches

…, P Navarra, G Staurenghi, M Stumpp, M Zarbin - International journal of …, 2020 - mdpi.com
Age-related macular degeneration (AMD) constitutes a prevalent, chronic, and progressive
retinal degenerative disease of the macula that affects elderly people and cause central …

High-affinity binders selected from designed ankyrin repeat protein libraries

HK Binz, P Amstutz, A Kohl, MT Stumpp, C Briand… - Nature …, 2004 - nature.com
We report here the evolution of ankyrin repeat (AR) proteins in vitro for specific, high-affinity
target binding. Using a consensus design strategy, we generated combinatorial libraries of …

Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins

HK Binz, MT Stumpp, P Forrer, P Amstutz… - Journal of molecular …, 2003 - Elsevier
We describe an efficient way to generate combinatorial libraries of stable, soluble and well-expressed
ankyrin repeat (AR) proteins. Using a combination of sequence and structure …

Long-term and trans-life-cycle effects of exposure to ocean acidification in the green sea urchin Strongylocentrotus droebachiensis

S Dupont, N Dorey, M Stumpp, F Melzner, M Thorndyke - Marine biology, 2013 - Springer
Anthropogenic CO 2 emissions are acidifying the world’s oceans. A growing body of
evidence demonstrates that ocean acidification can impact survival, growth, development and …

CO2 induced seawater acidification impacts sea urchin larval development I: elevated metabolic rates decrease scope for growth and induce developmental delay

M Stumpp, J Wren, F Melzner, MC Thorndyke… - … and Physiology Part A …, 2011 - Elsevier
… Spawning was induced in June–July 2008 and 2009 by intra-coelomic injection of 0.5 M
KCl in filtered seawater (FSW). In each experiment, gametes from three males and three …

Designed to be stable: crystal structure of a consensus ankyrin repeat protein

A Kohl, HK Binz, P Forrer, MT Stumpp… - Proceedings of the …, 2003 - National Acad Sciences
… These designed AR proteins show cooperative, reversible unfolding with midpoints of
unfolding between 2.9 and 5 M GdmCl and possess values for the free energy of unfolding (ΔG) …

Acidified seawater impacts sea urchin larvae pH regulatory systems relevant for calcification

M Stumpp, MY Hu, F Melzner… - Proceedings of the …, 2012 - National Acad Sciences
Calcifying echinoid larvae respond to changes in seawater carbonate chemistry with
reduced growth and developmental delay. To date, no information exists on how ocean …

Efficient tumor targeting with high-affinity designed ankyrin repeat proteins: effects of affinity and molecular size

C Zahnd, M Kawe, MT Stumpp, C de Pasquale… - Cancer research, 2010 - AACR
Slow-clearing, tumor-targeting proteins such as monoclonal antibodies typically exhibit high
tumor accumulation but low tissue contrast, whereas intermediate-sized proteins such as …