User profiles for M. Stumpp
Meike StumppChristian-Albrechts-Universität zu Kiel - Comparative Immunobiology Verified email at zoologie.uni-kiel.de Cited by 2325 |
Comprehensive survey of proteins targeted by chloroplast thioredoxin
K Motohashi, A Kondoh, MT Stumpp… - Proceedings of the …, 2001 - National Acad Sciences
… For that purpose, we immobilized a mutant of m-type Trx in which an internal cysteine at
the active site was substituted with serine, on cyanogen bromide-activated resin. By using this …
the active site was substituted with serine, on cyanogen bromide-activated resin. By using this …
DARPins: a new generation of protein therapeutics
MT Stumpp, HK Binz, P Amstutz - Drug discovery today, 2008 - Elsevier
DARPins (designed ankyrin repeat proteins) are a novel class of binding molecules with the
potential to overcome limitations of monoclonal antibodies, hence allowing novel …
potential to overcome limitations of monoclonal antibodies, hence allowing novel …
[HTML][HTML] Neovascular age-related macular degeneration: therapeutic management and new-upcoming approaches
…, P Navarra, G Staurenghi, M Stumpp, M Zarbin - International journal of …, 2020 - mdpi.com
Age-related macular degeneration (AMD) constitutes a prevalent, chronic, and progressive
retinal degenerative disease of the macula that affects elderly people and cause central …
retinal degenerative disease of the macula that affects elderly people and cause central …
High-affinity binders selected from designed ankyrin repeat protein libraries
HK Binz, P Amstutz, A Kohl, MT Stumpp, C Briand… - Nature …, 2004 - nature.com
We report here the evolution of ankyrin repeat (AR) proteins in vitro for specific, high-affinity
target binding. Using a consensus design strategy, we generated combinatorial libraries of …
target binding. Using a consensus design strategy, we generated combinatorial libraries of …
Designing repeat proteins: well-expressed, soluble and stable proteins from combinatorial libraries of consensus ankyrin repeat proteins
HK Binz, MT Stumpp, P Forrer, P Amstutz… - Journal of molecular …, 2003 - Elsevier
We describe an efficient way to generate combinatorial libraries of stable, soluble and well-expressed
ankyrin repeat (AR) proteins. Using a combination of sequence and structure …
ankyrin repeat (AR) proteins. Using a combination of sequence and structure …
Long-term and trans-life-cycle effects of exposure to ocean acidification in the green sea urchin Strongylocentrotus droebachiensis
Anthropogenic CO 2 emissions are acidifying the world’s oceans. A growing body of
evidence demonstrates that ocean acidification can impact survival, growth, development and …
evidence demonstrates that ocean acidification can impact survival, growth, development and …
CO2 induced seawater acidification impacts sea urchin larval development I: elevated metabolic rates decrease scope for growth and induce developmental delay
… Spawning was induced in June–July 2008 and 2009 by intra-coelomic injection of 0.5 M
KCl in filtered seawater (FSW). In each experiment, gametes from three males and three …
KCl in filtered seawater (FSW). In each experiment, gametes from three males and three …
Designed to be stable: crystal structure of a consensus ankyrin repeat protein
A Kohl, HK Binz, P Forrer, MT Stumpp… - Proceedings of the …, 2003 - National Acad Sciences
… These designed AR proteins show cooperative, reversible unfolding with midpoints of
unfolding between 2.9 and 5 M GdmCl and possess values for the free energy of unfolding (ΔG) …
unfolding between 2.9 and 5 M GdmCl and possess values for the free energy of unfolding (ΔG) …
Acidified seawater impacts sea urchin larvae pH regulatory systems relevant for calcification
Calcifying echinoid larvae respond to changes in seawater carbonate chemistry with
reduced growth and developmental delay. To date, no information exists on how ocean …
reduced growth and developmental delay. To date, no information exists on how ocean …
Efficient tumor targeting with high-affinity designed ankyrin repeat proteins: effects of affinity and molecular size
C Zahnd, M Kawe, MT Stumpp, C de Pasquale… - Cancer research, 2010 - AACR
Slow-clearing, tumor-targeting proteins such as monoclonal antibodies typically exhibit high
tumor accumulation but low tissue contrast, whereas intermediate-sized proteins such as …
tumor accumulation but low tissue contrast, whereas intermediate-sized proteins such as …