User profiles for Leon Chen

Leon Chen, DNP, AGACNP-BC, FCCP, FAANP, FCCM

Memorial Sloan Kettering Cancer Center, Columbia University School of Nursing
Verified email at mskcc.org
Cited by 225

Opposing cardioprotective actions and parallel hypertrophic effects of δPKC and ɛPKC

L Chen, H Hahn, G Wu, CH Chen… - Proceedings of the …, 2001 - National Acad Sciences
Conflicting roles for protein kinase C (PKC) isozymes in cardiac disease have been reported.
Here, δPKC-selective activator and inhibitor peptides were designed rationally, based on …

The RSNA pediatric bone age machine learning challenge

…, N Abdala, FC Kitamura, HH Thodberg, L Chen… - Radiology, 2019 - pubs.rsna.org
Purpose The Radiological Society of North America (RSNA) Pediatric Bone Age Machine
Learning Challenge was created to show an application of machine learning (ML) and artificial …

Inhibition of δ-protein kinase C protects against reperfusion injury of the ischemic heart in vivo

K Inagaki, L Chen, F Ikeno, FH Lee, K Imahashi… - Circulation, 2003 - Am Heart Assoc
Background— Current treatment for acute myocardial infarction (AMI) focuses on reestablishing
blood flow (reperfusion). Paradoxically, reperfusion itself may cause additional injury to …

Tobacco smoking during radiation therapy for head-and-neck cancer is associated with unfavorable outcome

AM Chen, LM Chen, A Vaughan, R Sreeraman… - International Journal of …, 2011 - Elsevier
PURPOSE: To evaluate the effect of continued cigarette smoking among patients undergoing
radiation therapy for head-and-neck cancer by comparing the clinical outcomes among …

An 8‐year retrospective study: 1,100 patients receiving 1,557 implants using the minimally invasive hydraulic sinus condensing technique

L Chen, J Cha - Journal of Periodontology, 2005 - Wiley Online Library
Background: For many clinicians, inadequate alveolar bone height and anatomical features
of the maxillary sinus complicate sinus lift procedures and placement of endosseous …

Noncontact wearable wireless ECG systems for long-term monitoring

…, L Chen, O Marinov, CH Chen… - IEEE reviews in …, 2018 - ieeexplore.ieee.org
Electrocardiography (ECG) is the most common and extensively used vital sign monitoring
method in modern healthcare systems. Different designs of ambulatory ECG systems were …

[PDF][PDF] Molecular transporters for peptides: delivery of a cardioprotective ϵPKC agonist peptide into cells and intact ischemic heart using a transport system, R7

L Chen, LR Wright, CH Chen, SF Oliver, PA Wender… - Chemistry & biology, 2001 - cell.com
Background: Recently, we reported a novel oligoguanidine transporter system, polyarginine
(R 7 ), which, when conjugated to spectroscopic probes (eg, fluorescein) and drugs (eg, …

Freeway ramp control using fuzzy set theory for inexact reasoning

LL Chen, AD May, DM Auslander - Transportation Research Part A …, 1990 - Elsevier
This paper presents a fuzzy controller for freeway ramp metering, which uses rules of the
form: IF “freeway condition” THEN “control action.” The controller has been designed to …

Necrotizing fasciitis: a comprehensive review

LL Chen, B Fasolka, C Treacy - Nursing2023, 2020 - journals.lww.com
Necrotizing soft-tissue infections (NSTIs) are rare but rapidly progressive, lifethreatening
bacterial infections with high morbidity and mortality. NSTIs include necrotizing forms of fasciitis, …

Vertebrate animal models of glioma: understanding the mechanisms and developing new therapies

L Chen, Y Zhang, J Yang, JP Hagan, M Li - Biochimica et Biophysica Acta …, 2013 - Elsevier
Glioblastoma Multiforme (GBM) is recognized as one of the most deadly cancers characterized
by cellular atypia, severe necrosis, and high rate of angiogenesis. In this review, we …