Deep brain stimulation (DBS) of the subthalamic nucleus markedly improves the motor
symptoms of Parkinson's disease, but causes cognitive side effects such as impulsivity. We …

What are the genetic and neural components that support adaptive learning from positive
and negative outcomes? Here, we show with genetic analyses that three independent …

Parkinson’s disease (PD) is characterized by a range of motor symptoms. Besides the cardinal
symptoms (akinesia and bradykinesia, tremor and rigidity), PD patients show additional …

In this article, we argue that motor and cognitive processes are functionally related and most
likely share a similar evolutionary history. This is supported by clinical and neural data …

The cerebellum has been considered for a long time to play a role solely in motor coordination.
However, studies over the past two decades have shown that the cerebellum also plays …

Recent neuroimaging evidence has led to the proposal that freezing of gait in Parkinson's
disease is due to dysfunctional interactions between frontoparietal cortical regions and …

Clustering is a powerful machine learning tool for detecting structures in datasets. In the
medical field, clustering has been proven to be a powerful tool for discovering patterns and …

Parkinson's disease (PD) patients exhibit cognitive deficits, including reinforcement learning,
working memory (WM) and set shifting. Computational models of the basal ganglia–frontal …

There is a growing body of research focused on the relationship between childhood trauma
and the risk of developing psychosis. Numerous studies, including many large-scale …

Schizophrenia and bipolar disorder (BD) are complex and multidimensional disorders with
high heritability rates. The contribution of genetic factors to the etiology of these disorders is …